DATABASES ON MEDICINE AND MOLECULAR BIOLOGY
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13th Report on Carcinogens
 

The Report on Carcinogens is producec by
U.S. Department of Health and Human Services, Public Health Service,
National Toxicology Program

https://ntp.niehs.nih.gov/pubhealth/roc/index.html

Chemical Carcinogenesis Research Information System
 

Chemical Carcinogenesis Research Information System - carcinogenicity, mutagenicity, tumor promotion, and tumor inhibition data provided by the National Cancer Institute (NCI).
https://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?CCRIS

Catalogue Of Somatic Mutations In Cancer"  info
 

COSMIC (Catalogue of Somatic Mutations in Cancer; http://www.sanger.ac.uk/cosmic) is a comprehensive resource that aims to curate the world's literature on somatic mutations in known cancer genes. The catalog includes full and up-to-date curation of mutation data in over 60 well known point-mutated genes, together with novel gene fusion products expressed across genome rearrangement breakpoints, and all of the somatic mutation data from candidate gene screens at the UK's Cancer Genome Project.
http://www.sanger.ac.uk/cosmic

The Carcinogenic Potency Database"  info
 

The CPDB is a standardized resource on chronic, long-term animal cancer tests. CPDB provides ...
- Quick access to results on 1451 chemicals
- Analyses of experimental design for each of 6008 experiments, including species, strain, dose and protocol
-Analyses of tumor incidence at each target site, dose-response curve shape, carcinogenic potency and statistical significance
https://toxnet.nlm.nih.gov/cpdb/cpdb.html

Database of MHC Ligands"  info
 

EPIMHC is a relational database of MHC-binding peptides and T cell epitopes that are observed in real proteins. Currently, the database contains 4867 distinct peptide sequences from various sources, including 84 tumor-associated antigens.
http://bio.dfci.harvard.edu/epimhc/

Human Endogenous Retrovirus Database"  info
 

Retroviral genomes or parts of their genomes are present in the DNA of many organisms. Studies of endogenous retroviral nucleotide sequences have become an important part of contemporary retrovirology as well as of molecular and cellular biology and genomics. Human endogenous retroviruses (HERVs) are of special interest also because their expression may be associated with several diseases, including cancer. Various groups of HERVs have been reported in the human genome. Their number can range from one copy to many thousand copies.
http://herv.img.cas.cz

Integrated Risk Information System"  info
 

Integrated Risk Information System - data from the EPA in support of human health risk assessment, focusing on hazard identification and dose-response assessment.
https://www.epa.gov/iris

Myc Cancer Gene"  info
 

Diese Website enthält Links zu folgenden Datenbanken:

  • Myc Target Gene Database
  • Myc and Human Cancer Database
  • Myc Protein - Protein Interaction Database
    http://www.myc-cancer-gene.org/

  • Nuclear Matrix Associated Proteins - Database"  info
     

    NMP-db is a database of nuclear matrix associated proteins, produced by Sven Mika @ Rost Group, Columbia University, New York.
    http://www.rostlab.org/services/NMPdb/

    Cancer Microarray Database - Oncomine
     

    ONCOMINE collects all publicly available cancer microarray studies.
    https://www.oncomine.org/

    IARC TP53 Mutation Database"  info
     

    In 1991, a database of TP53 somatic mutations in human cancers and cell-lines was initiated by Monica Hollstein and Curtis Harris. Since 1994, this database has been maintained at the International Agency for Research on Cancer (IARC) in Lyon, France and is made freely available as a service to the scientific community.
    The IARC TP53 Mutation Database is now maintained by the Unit of Molecular Carcinogenesis (MOC) at IARC, under the supervision of Pierre Hainaut.
    The project consists of three aspects:
    Perform regular review of the TP53 mutation literature
    Develop electronic formats for compiling, sorting and retrieving mutation data
    Perform research on TP53 mutation patterns
    http://www-p53.iarc.fr/

    The Wnt gene Homepage
     

    Wnt proteins form a family of highly conserved secreted signaling molecules that regulate cell-to-cell interactions during embryogenesis. Wnt genes and Wnt signaling are also implicated in cancer. Insights into the mechanisms of Wnt action have emerged from several systems: genetics in Drosophila and Caenorhabditis elegans; biochemistry in cell culture and ectopic gene expression in Xenopus embryos. Many Wnt genes in the mouse have been mutated, leading to very specific developmental defects.
    http://www.stanford.edu/group/nusselab/cgi-bin/wnt/