[German]  [Feedback]


Gene Regulation by Mammalian micro-RNAs

MicroRNAs (miRNAs) constitute a class of small non-coding RNAs that regulate expression of target genes either by decreasing the stability of the target mRNA or by translational inhibition. They are involved in diverse processes, including cellular differentiation, proliferation and apoptosis. Recent evidence also suggests their importance for cancerogenesis. By far the most important model systems in cancer research are mammalian organisms. Argonaute compiles comprehensive information on mammalian miRNAs, their origin and regulated target genes in an exhaustive database.

ArrayExpress"  info

ArrayExpress is a public database of gene expression experiments. These experiments consist of multiple parts (or objects), in order to simplify querying we have provided a query interface which allows you to retrieve the most useful information relating to each experiment, the array(s) and the protocols(s) used.

Xenopus laevis Database Focusing on Gene Expression"  info

Axeldb is a database storing and integrating gene expression patterns and DNA sequences identified in a large-scale in situ hybridization study in Xenopus laevis embryos. The database was developed at the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) in Heidelberg.

CleanEx"  info

CleanEx is a database which provides access to public gene expression data via unique approved gene symbols and which represents heterogeneous expression data produced by different technologies in a way that facilitates joint analysis and cross-dataset comparisons.

Edinburgh Mouse Atlas Project

The Edinburgh Mouse Atlas consists of a digital atlas of mouse embryo development and spatially-mapped gene expression.

Endocrine Pancreas Consortium Database"  info

Genexpression database of the Endocrine Pancreas Consortium.

Erythropoiesis Database"  info

The EpoDB (Erythropoiesis database) is a database of genes that relate to vertebrate red blood cells. It includes DNA sequence, structural features, protein information, gene expression information and transcription factor binding sites. The database ist provided by the Computational Biology and Informatics Laboratory at the University of Pennsylvania.

Microarray Gene Annotation (GeneAnnot)"  info

Revised and improved annotation of Affymetrix human gene probe sets.

"  info

GeneNote is a database of human genes and their expression profiles in healthy tissues. It is based on Weizmann Institute of Science DNA array experiments, which were performed on the Affymetrix HG-U95 set A-E. It offers:

  • An expression profile (tissue vector) for each gene in the human genome
  • Gene and tissue clustering based on expression profiles
  • A full genome ranking procedure according to the gene's tendency for tissue specificity, from tissue-specific to housekeeping genes.

  • GenePaint"  info

    GenePaint is a digital atlas of gene expression patterns in the mouse.


    Genevestigator is one of the world's largest quality-controlled, curated and annotated databases of mouse Affymetrix arrays, and offers unique querying possibilities for molecular biologists.

    Gene Expression Omnibus"  info

    The Gene Expression Omnibus is a high-throughput gene expression / molecular abundance data repository, as well as a curated, online resource for gene expression data browsing, query and retrieval. GEO became operational in July 2000.

    GermOnline"  info

    GermOnline is a database that provides access to microarray expression data from experiments relevant for the mitotic and meiotic cell cycle as well as gametogenesis in yeast and higher eukaryotes. In addition to that, GermOnline integrates knowledge about genes important for sexual reproduction.

    Mouse Gene Expression Database

    Gene expression database from the mouse.

    Heart and Calcium Functional Network (HCNet) Database

    The Heart and Calcium functional Network (HCNet) database is a collection of functional gene modules calculated from the microarray data compendium available from the GEO database. It is a specialized database designed to assist experimentalists for cardiac calcium signaling research by providing the pre-calculated gene clusters and their potential correlation network in heart.

    Hembase"  info

    Hembase is an integrated browser and genome portal designed for web-based examination of the human erythroid transcriptome.

    Human Gene Expression Index (HuGE Index)"  info

    Human Gene Expression Index (HuGE Index) aims to provide a comprehensive database to aid in understanding the expression of human genes in normal human tissues.
    The mRNA expression levels of thousands of genes in a collection of normal human organs were obtained using high-density oligonucleotide array technology and deposited in this public database.

    Interferon Stimulated Gene Database

    Database about genes induced by treatment with interferons.

    Kidney Development Database

    The Kidney Development Database was created to collect in one place the data from a large number of developmental studies that have a bearing on the study of kidney development.

    DNA Methylation Database"  info

    Database of DNA methylation.

    NetAffx Analysis Center"  info

    NetAffx details and annotates probesets on Affymetrix GeneChip microarrays. These annotations include (i) static information specific to the probeset composition; (ii) sequence annotations extracted from public databases; and (iii) protein sequence-level annotations derived from public domain programs, as well as libraries of hidden Markov models (HMMs) developed at Affymetrix.

    Public Expression Profiling Resource (pepr)"  info

    Public expression profiling resource provides expression profiles in a variety of diseases and conditions.

    Database of the Translational Recoding Events (recode)"  info

    The RECODE database is a compilation of translational recoding events (programmed ribosomal frameshifting, codon redefinition and translational bypass). The database provides information about the genes utilizing these events for their expression, recoding sites, stimulatory sequences and other relevant information.

    REFerence database for Gene EXpression Analysis"  info

    Database for gene expression analysis.

    Stanford Microarray Database"  info

    SMD stores raw and normalized data from microarray experiments, as well as their corresponding image files. In addition, SMD provides interfaces for data retrieval, analysis and visualization.

    Stanley Medical Research Institute Online Genomics Database"  info

    The Stanley Medical Research Institute online genomics database (SMRIDB) is a web-based system for understanding the genetic effects of human brain disease (i.e. bipolar, schizophrenia, and depression). This database contains fully annotated clinical metadata and gene expression patterns.

    Transcription Element Listening System (TELiS)"  info

    TELiS combines sequence-based analysis of gene regulatory regions with statistical prevalence analyses to identify transcription-factor binding motifs (TFBMs) that are over-represented among the promoters of up- or down-regulated genes. TELiS thus provides a simple, rapid and sensitive tool for identifying transcription control pathways mediating observed gene expression dynamics.

    Tissue-Specific Promoter Database

    TiProD is a database of human promoter sequences for which some functional features are known. It allows a user to query individual promoters and the expression pattern they mediate, gene expression signatures of individual tissues, and to retrieve sets of promoters according to their tissue-specific activity or according to individual Gene Ontology terms the corresponding genes are assigned to.

    Gene Expression in Tooth

    Database about the geneexpression in tooth.

    WebQTL Project"  info

    WebQTL stors data about gene expression, neuropharmacological,anatomical, and behavioral data for over 30 strains of mice.